Diagnosis of cystic echinococcosis (CE) is at present mainly based on imaging techniques. Serology has a complementary role, partly due to the small number of standardized and commercially available assays. Therefore we examined the clinical performance of the SERION ELISA classic Echinococcus IgG test. Using 10 U/ml as a cut-off point, and serum samples from 50 CE patients and 105 healthy controls, the sensitivity and specificity were 98.0% and 96.2%, respectively. If patients with other infectious diseases were used as negative controls, the specificity decreased to 76.9%, which causes poor positive predictive values. However, if results between 10 and 15 U/ml are classified as indecisive, the specificity of positive results (≥15 U/ml) increased to 92.5% without greatly affecting the sensitivity (92.0%). Using this approach in combination with imaging studies, the SERION ELISA classic Echinococcosis IgG test can be a useful aid in the diagnosis of CE.

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Keywords cystic echinococcosis, diagnosis, Echinococcus granulosus, ELISA, serology
Persistent URL dx.doi.org/10.1017/s0022149x18000536, hdl.handle.net/1765/118898
Journal Journal of Helminthology
Sarink, M.J., Koelewijn, R, Slingerland, B.M., Tielens, A.G.M, van Genderen, P.J.J, & van Hellemond, J.J. (2019). Performance of the commercially available SERION ELISA classic Echinococcus IgG test for the detection of cystic echinococcosis in clinical practice. Journal of Helminthology, 93(5), 636–639. doi:10.1017/s0022149x18000536