A proper functional thymus is required for generation of T cell–mediated immunity. This is dramatically illustrated by patients lacking a thymus, such as children with complete DiGeorge syndrome, which is fatal if left untreated.1-3 Therapeutic options for such patients are limited and confined to transplantation of small fragments from allogeneic neonatal thymi.

doi.org/10.1016/j.jaci.2019.05.042, hdl.handle.net/1765/118979
Journal of Allergy and Clinical Immunology
Department of Hematology

Chhatta, A.R. (Amiet R.), Cordes, M. (Martijn), Hanegraaf, M.A.J. (Maaike A.J.), Vloemans, S. (Sandra), Cupedo, T., Cornelissen, J., … Staal, F. (2019). De novo generation of a functional human thymus from induced pluripotent stem cells. Journal of Allergy and Clinical Immunology. doi:10.1016/j.jaci.2019.05.042