2019
De novo generation of a functional human thymus from induced pluripotent stem cells
Publication
Publication
A proper functional thymus is required for generation of T cell–mediated immunity. This is dramatically illustrated by patients lacking a thymus, such as children with complete DiGeorge syndrome, which is fatal if left untreated.1-3 Therapeutic options for such patients are limited and confined to transplantation of small fragments from allogeneic neonatal thymi.
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| doi.org/10.1016/j.jaci.2019.05.042, hdl.handle.net/1765/118979 | |
| Journal of Allergy and Clinical Immunology | |
| Organisation | Department of Hematology |
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Chhatta, A.R. (Amiet R.), Cordes, M. (Martijn), Hanegraaf, M.A.J. (Maaike A.J.), Vloemans, S. (Sandra), Cupedo, T., Cornelissen, J., Carlotti, F., Salvatori, D., Pike, K., Fibbe, W., Hoeben, R., Mikkers, H.& Staal, F. (2019). De novo generation of a functional human thymus from induced pluripotent stem cells. Journal of Allergy and Clinical Immunology.https://doi.org/10.1016/j.jaci.2019.05.042 |
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