In this thesis, (intravascular) imaging, pathobiology and biomechanical modelling were combined to:
1) describe existing animal models for atherosclerosis and discuss the role biomechanics play in plaque development in these models;
2) further elucidate the involvement of the biomechanical factors wall shear stress and helical flow in the development of coronary atherosclerotic plaques, and to assess the potential of these biomechanical factors and of specific lipoproteins as new biomarkers for atherosclerotic disease development;
3) extend the interpretation of imaging data derived from two commonly used invasive imaging techniques to improve plaque and patient risk-stratification.

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Keywords coronary atherosclerosis, invasive imaging, biomechanics, lipoproteins, biomarkers, histopathology, animal models
Promotor A.F.W. van der Steen (Ton) , D.J.G.M. Duncker (Dirk) , J.J. Wentzel (Jolanda)
Publisher Erasmus University Rotterdam
Sponsor The research described in this PhD thesis has received funding from the European Research Council under the European Union’s Seventh Framework Programme / ERC Grant Agreement nr. 310457.
ISBN 978-94-6375-503-0
Persistent URL
Hoogendoorn, A. (2019, September 19). Coronary Atherosclerosis- imaging, biology and mechanics. Erasmus University Rotterdam. Retrieved from