Background: The aim of this study was to investigate the impact of ticagrelor monotherapy following 1-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for bifurcation lesions. Methods: GLOBAL LEADERS was a randomized, superiority, all-comers trial comparing 1-month DAPT with ticagrelor and aspirin followed by 23-month ticagrelor monotherapy (experimental treatment) with standard 12-month DAPT followed by 12-month aspirin monotherapy (reference treatment) in patients treated with a biolimus A9-eluting stent. The primary endpoint was a composite of all-cause death or new Q-wave myocardial infarction (MI) at 2 years. Results: Among the 15,845 patients included in this subgroup analysis, 2,498 patients (15.8%) underwent PCI for at least one bifurcation lesion. The incidence of the primary endpoint was similar between the bifurcation and nonbifurcation groups (4.7 vs. 4.0%, p =.083). The experimental treatment had no significant effect on the primary endpoint according to the presence/absence of a bifurcation lesion (bifurcation: hazard ratio [HR]: 0.74, 95% confidence interval [CI]: 0.51–1.07; nonbifurcation: HR: 0.90, 95% CI: 0.76–1.07, p for interaction =.343), but was associated with significant reduction in definite or probable stent thrombosis (p for interaction =.022) and significant excess of stroke (p for interaction =.018) when compared with the reference treatment. Conclusions: After PCI for bifurcation lesions using 1-month of DAPT followed by ticagrelor monotherapy for 23 months did not demonstrate explicit benefit regarding all-cause death or new Q-wave MI as in the overall trial.

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Keywords antiplatelet treatment, bifurcation lesion, drug-eluting stents, Percutaneous coronary intervention
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Journal Catheterization and Cardiovascular Interventions
Kogame, N, Chichareon, P. (Ply), De Wilder, K. (Kenneth), Takahashi, K, Modolo, R. (Rodrigo), Chang, C.C. (Chun Chin), … Serruys, P.W.J.C. (2019). Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial. Catheterization and Cardiovascular Interventions. doi:10.1002/ccd.28428