Signal transducer and activator of transcription molecules (STATs) are messenger molecules that play a very important role in the function of cells. Dysfunction of these STATs leads to an immunodeficiency disorder and/or autoimmunity. This was studied in detail in the dissertation on the basis of patients with a genetic mutation in the STAT1 and STAT3 gene.

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Keywords immunodeficiency, STAT1, STAT3, autoimmunity, JAK-inhibitors, mutations, mitochondria
Promotor P.M. van Hagen (Martin) , V.A.S.H. Dalm (Virgil) , W.A. Dik (Willem)
Publisher Erasmus University Rotterdam
ISBN 978-94-91811-23-4
Persistent URL
Note For copyright reasons there is a (partial) embargo for this dissertation
Meesilpavikkai, K. (2019, October 9). The State of STATs in Primary Immunodeficiencies : Molecular Diversity and Implications for Therapy. Erasmus University Rotterdam. Retrieved from