The overall aim of this thesis was to investigate the role of angiogenic factors, micronutrients involved in the homocysteine metabolism, and maternal blood pressure, in relation to maternal and child health during and after pregnancy. The questions to be addressed in this thesis are:
Part I: Maternal health
1) Do homocysteine, folate and vitamin B12 concentrations affect placental development and subsequently maternal and child health during pregnancy?
2) To what extent do maternal gestational blood pressure and hypertensive pregnancy disorders influence maternal cardiometabolic outcomes six years after delivery?
Part II: Child health
3) How do early pregnancy and umbilical cord blood markers of the homocysteine pathway and angiogenic markers relate to fetal and childhood growth?
4) Is maternal blood pressure associated with childhood blood pressure?

Additional Metadata
Promotor E.A.P. Steegers (Eric) , V.W.V. Jaddoe (Vincent) , S. Schalekamp-Timmermans (Sarah)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-298-2
Persistent URL
Bergen, N.E. (2019, October 16). Vascular health in pregnancy; maternal and child outcomes : The Generation R study. Erasmus University Rotterdam. Retrieved from