2019-12-01
Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning
Publication
Publication
Neuroscience & Biobehavioral Reviews , Volume 107 p. 329- 345
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.
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| , , , , , , , , , , , , , , | |
| doi.org/10.1016/j.neubiorev.2019.09.020, hdl.handle.net/1765/119918 | |
| Neuroscience & Biobehavioral Reviews | |
| Organisation | Department of Psychology |
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Haaker, J. (Jan), Maren, S. (Stephen), Andreatta, M. (Marta), Merz, C.J. (Christian J.), Richter, J. (Jan), Richter, S.H. (S. Helene), … Lonsdorf, T.B. (Tina B.). (2019). Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. Neuroscience & Biobehavioral Reviews (Vol. 107, pp. 329–345). doi:10.1016/j.neubiorev.2019.09.020 |
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