2019-10-21
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
Publication
Publication
Angewandte Chemie (International ed. in English) , Volume 58 - Issue 43 p. 15390- 15395
Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small-molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid-polymer amphiphiles for optimized lymphoid targeting.
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| doi.org/10.1002/anie.201905687, hdl.handle.net/1765/120256 | |
| Angewandte Chemie (International ed. in English) | |
| Organisation | Department of Pulmonology |
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De Vrieze, J. (Jana), Louage, B. (Benoit), Deswarte, K., Zhong, Z. (Zifu), De Coen, R. (Ruben), Van Herck, S. (Simon), … De Geest, B.G. (Bruno G.). (2019). Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. Angewandte Chemie (International ed. in English), 58(43), 15390–15395. doi:10.1002/anie.201905687 |
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