Cachexia is a clinical condition characterized by muscle wasting, anorexia and metabolic change. It is associated with a wide variety of clinical conditions, including cancer. Clinically it is rarely recognized prior to end-stage disease. Computed tomography (CT) imaging has made it possible to detect differences in skeletal muscle mass early on in the course of disease.
The aim of the studies in this thesis was to describe the clinical impact of low skeletal muscle mass on overall survival and disease-free survival in surgical oncology and liver transplant patients. And to investigate potential treatment strategies in experimental cancer-associated cachexia animal models.

Additional Metadata
Keywords sarcopenia, cachexia, skeletal muscle mass, computed tomography, cancer, colorectal cancer, hepatocellular carcinoma, cirrhosis, liver transplantation, experimental treatment, quercetin, sb431542, gw788388, caloric restriction
Promotor J.N.M. IJzermans (Jan) , R.W.F. de Bruin (Ron)
Publisher Erasmus University Rotterdam
ISBN 978-94-6380-539-1
Persistent URL
Note For copyright reasons there is a partial embargo for this dissertation
Levolger, S. (2019, November 12). Skeletal Muscle Wasting: Clinical implications and experimental treatment. Erasmus University Rotterdam. Retrieved from