Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2
Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.
|Keywords||ellipsoid zone – en face image – MacTel – macular telangiectasia type 2 – OCT|
|Persistent URL||dx.doi.org/10.1111/aos.14110, hdl.handle.net/1765/121281|
Pauleikhoff, D., Bonelli, R., Dubis, A.M., Gunnemann, F., Rothaus, K., & Issa, P.C. (2019). Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2. Acta Ophthalmologica, 97(7), E998–E1005. doi:10.1111/aos.14110