The properties of hematopoietic stem cells (HSCs) including quiescence, proliferation and differentiation are maintained by both intrinsic programs from HSCs and extrinsic signals from the bone marrow micro-environment, also known as the HSC niche. In this dissertation, we aim to provide answers to the following research questions: what are the molecular events underlying the HSC niche-driven clonal transformation of hematopoiesis, and what is the relevance of these molecular events to human diseases?

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Keywords Hematopoietic stem cell, microenvironment, mesenchymal niche, bone marrow failure, acute myeloid leukemia, myelodysplastic syndromes, shwachman-diamond syndrome, neutropenia, S100A8/9, NF-kB, p53, TLR4
Promotor M.H.G.P. Raaijmakers (Marc H.G.P.) , I.P. Touw (Ivo)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-344-6
Persistent URL
Ping, Z. (2019, November 19). The Hematopoietic Stem Cell Niche in Leukemia Predisposition. Erasmus University Rotterdam. Retrieved from