The properties of hematopoietic stem cells (HSCs) including quiescence, proliferation and differentiation are maintained by both intrinsic programs from HSCs and extrinsic signals from the bone marrow micro-environment, also known as the HSC niche. In this dissertation, we aim to provide answers to the following research questions: what are the molecular events underlying the HSC niche-driven clonal transformation of hematopoiesis, and what is the relevance of these molecular events to human diseases?

Additional Metadata
Keywords Hematopoietic stem cell, microenvironment, mesenchymal niche, bone marrow failure, acute myeloid leukemia, myelodysplastic syndromes, shwachman-diamond syndrome, neutropenia, S100A8/9, NF-kB, p53, TLR4
Promotor M.H.G.P. Raaijmakers (Marc H.G.P.) , I.P. Touw (Ivo)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-344-6
Persistent URL hdl.handle.net/1765/121450
Citation
Ping, Z. (2019, November 19). The Hematopoietic Stem Cell Niche in Leukemia Predisposition. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/121450