The properties of hematopoietic stem cells (HSCs) including quiescence, proliferation and differentiation are maintained by both intrinsic programs from HSCs and extrinsic signals from the bone marrow micro-environment, also known as the HSC niche. In this dissertation, we aim to provide answers to the following research questions: what are the molecular events underlying the HSC niche-driven clonal transformation of hematopoiesis, and what is the relevance of these molecular events to human diseases?

Hematopoietic stem cell, microenvironment, mesenchymal niche, bone marrow failure, acute myeloid leukemia, myelodysplastic syndromes, shwachman-diamond syndrome, neutropenia, S100A8/9, NF-kB, p53, TLR4
M.H.G.P. Raaijmakers (Marc H.G.P.) , I.P. Touw (Ivo)
Erasmus University Rotterdam
Department of Hematology

Ping, Z. (2019, November 19). The Hematopoietic Stem Cell Niche in Leukemia Predisposition. Erasmus University Rotterdam. Retrieved from