Impact of acute-on-chronic liver failure on post-transplant survival and on kidney outcomes
Objectives We aimed to evaluate the effect of acute-on-chronic liver failure (ACLF) on patients’ 1-year post-liver transplant (LT) survival. In addition, we evaluated the effect of ACLF on the development of post-LT chronic kidney disease (CKD) and early allograft dysfunction (EAD). Patients and methods A retrospective cohort of patients who underwent transplantation from 2010 to 2016 was studied. EASL-CLIF’s definition of ACLF was used. The risk of post-LT death, CKD, and EAD was estimated with regression models weighted by inverse probability weighting considering the recipients’ characteristics. Donor’s BMI and donor risk index were included in the models as well. Results A total of 185 patients were included: 125 (67.6%) without ACLF and 60 (32.4%) with ACLF. The 1-year post-LT survival rate was 91.2% [95% confidence interval (CI): 84.6–95.1%] in patients without ACLF versus 84.9% (95% CI: 73.1–91.9%) in patients with ACLF. Post-LT CKD occurred in 43 (38.7%) patients without ACLF versus 26 (52.0%) patients with ACLF. EAD occurred in 40 (32.3%) patients without ACLF versus 15 (28.8%) patients with ACLF. No effect of ACLF was found on survival (hazard ratio 1.75; 95% CI: 0.64–4.75, P =0.272), CKD (odds ratio: 1.31; 95% CI: 0.60–2.86; P= 0.491), or EAD (odds ratio: 0.74; 95% CI: 0.38–1.66, P=0.473). Conclusion In this study, which included mainly patients with grade 1 ACLF at the time of LT, its presence had no impact on post-LT survival or on the occurrence of CKD or EAD. Eur J Gastroenterol Hepatol 31: 1157–1164 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
|Keywords||acute-on-chronic liver failure, chronic kidney disease, chronic renal failure, critically ill, graft failure, graft function, mortality, organ failure, transplantation|
|Persistent URL||dx.doi.org/10.1097/meg.0000000000001467, hdl.handle.net/1765/121535|
|Journal||European Journal of Gastroenterology and Hepatology|
Marciano, S., Mauro, E., Giunta, D., Torres, M.C., Diaz, J.M., Bermudez, C., … Gadano, A. (2019). Impact of acute-on-chronic liver failure on post-transplant survival and on kidney outcomes. European Journal of Gastroenterology and Hepatology, 31(9), 1157–1164. doi:10.1097/meg.0000000000001467