Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) is a difficult-to-treat pathogen due to its multidrug-resistant phenotype. Cardiac surgery patients are at increased risk of developing KPC-KP infections compared to other populations, with previous KPC-KP colonization being a critical factor in influencing the risk of subsequent infection. Two different pieces of information are essential to comprehensively assess the local characteristics of KPC-KP colonization in cardiac surgery patients: (i) the local prevalence of colonization; (ii) the timing of colonization. Treatment of KPC-KP infections in cardiac surgery patients is a complex task, but more effective treatment options have recently become available. Nonetheless, implementation and full adherence to infection-control measures remain of pivotal importance for reducing the burden of KPC-KP infections in this peculiar population. The aim of this narrative review is to summarize the available literature on the epidemiology and outcome of KPC-KP infections in cardiac surgery patients.

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Keywords Cardiac surgery, Colonization, DSWI, Klebsiella, KPC, Open heart surgery, VAP
Persistent URL dx.doi.org/10.1080/1120009X.2019.1685794, hdl.handle.net/1765/121645
Journal Journal of Chemotherapy
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Del Puente, F. (Filippo), Giacobbe, D.R. (Daniele R.), Salsano, A. (Antonio), Maraolo, A.E. (Alberto E.), Ong, D.S.Y. (David S.Y.), Yusuf, E, … Viscoli, C. (Claudio). (2019). Epidemiology and outcome of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) infections in cardiac surgery patients: a brief narrative review. Journal of Chemotherapy. doi:10.1080/1120009X.2019.1685794