Edible marine algae, or seaweeds, are a rich source of several bioactive compounds including phytosterols, carotenoids, and polysaccharides. Over the last decades, seaweed-derived constituents turned out to not only reside in the systemic circulation, but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions. Therefore, seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties, rendering them interesting candidates for the management of several neurodegenerative disorders. In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity, enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties. Though, the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids, phenols and polysaccharides have recently gained more interest. In this review, we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

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doi.org/10.4103/1673-5374.268894, hdl.handle.net/1765/121648
Neural Regeneration Research
Department of Internal Medicine

Schepers, M. (Melissa), Martens, N. (Nikita), Tiane, A. (Assia), Vanbrabant, K. (Kenneth), Liu, H.-B. (Hong-Bing), Lütjohann, D., … Vanmierlo, T. (2020). Edible seaweed-derived constituents: An undisclosed source of neuroprotective compounds. Neural Regeneration Research (Vol. 15, pp. 790–795). doi:10.4103/1673-5374.268894