Surgical repair of aortic coarctation in adults: half a century of a single centre clinical experience
OBJECTIVES: Coarctation of the aorta (CoA) is rarely diagnosed and treated in adults and nowadays mostly treated with percutaneous techniques. The objective of this study is to report the long-term outcomes and health-related quality of life in a unique cohort of patients treated with an open surgical repair for their primary adult CoA. METHODS: Ninety adult patients underwent primary surgical repair of CoA at our tertiary referral centre between 1961 and 2008 when the treatment strategy for adult CoA was exclusively surgical. RESULTS: The median age at surgery was 24 years (interquartile range 20-36 years), and 39 patients (43%) were asymptomatic at presentation. CoA was located paraductally in most patients (64%), and bicuspid aortic valve was present in 39 (43%) patients. Surgical reconstruction of CoA with an end-to-end anastomosis was performed in majority of the patients (57%). Overall, in-hospital mortality occurred in 1 patient (1%). There was no in-hospital stroke, spinal cord ischaemia, renal replacement therapy or respiratory failure. The cumulative survival was 97.7%, 89.5%, 82.6%, 70.9% and 61.4% at 10, 20, 30, 40 and 50 years, respectively. Thirty-one patients (34%) required an additional cardiac surgery during follow-up. The majority of patients (77%) suffered from refractory hypertension even after decades of surgery. Compared with the matched Dutch population, patients reported a lower social functioning, mental health, vitality and general health with a higher body pain. CONCLUSIONS: Patients with native adult CoA have low in-hospital morbidity and mortality when treated with an open surgical reconstruction. However, refractory hypertension and impaired quality of life remain important challenges during follow-up.
|Keywords||Adult, Coarctation, Health-related quality of life, Surgical repair|
|Persistent URL||dx.doi.org/10.1093/ejcts/ezz259, hdl.handle.net/1765/121798|
|Journal||European Journal of Cardio-Thoracic Surgery|
Abjigitova, D. (Djamila), Mokhles, M.M, Witsenburg, M, van de Woestijne, P.C, Bekkers, J.A, & Bogers, A.J.J.C. (2019). Surgical repair of aortic coarctation in adults: half a century of a single centre clinical experience. European Journal of Cardio-Thoracic Surgery, 56(6), 1178–1185. doi:10.1093/ejcts/ezz259