Rheumatoid Arthritis (RA) is common in the reproductive age. Women with RA have an impaired fertility related to the use of certain medication and active disease. RA usually improves during pregnancy, however almost half of the patients still have active disease in third trimester. Pregnancy outcomes are slightly less favorable, especially in women with high disease activity. Managing RA during pregnancy is challenging, because treatment options are limited. Accumulating evidence shows the safety of Tumor Necrosis Factor inhibitors in pregnant RA patients and patients with a wish to conceive. This paper reviews the current perspective on fertility, pregnancy and childbirth in women with RA and discusses treatment options before and during pregnancy.

Additional Metadata
Keywords Disease activity, Fertility, Pregnancy, Rheumatoid Arthritis, Tumor Necrosis Factor Inhibitor
Persistent URL dx.doi.org/10.1016/j.semarthrit.2019.09.010, hdl.handle.net/1765/121906
Journal Seminars in Arthritis and Rheumatism
Smeele, H.T.W. (H. T.W.), & Dolhain, R.J.E.M. (2019). Current perspectives on fertility, pregnancy and childbirth in patients with Rheumatoid Arthritis. Seminars in Arthritis and Rheumatism, 49(3), S32–S35. doi:10.1016/j.semarthrit.2019.09.010