2008-04-17
Molecular-genetic insights in pediatric T-cell acute lymphoblastic leukemia
Publication
Publication
Moleculair genetische inzichten in T-cel acute lymfatische leukemie bij kinderen
T-ALL is an aggressive T-cell malignancy with an inferior treatment outcome compared to B-lineage ALL. Intensive T-ALL research efforts during the last years lead to the identification of multiple genetic abnormalities that cooperate in the malignant transformation of thymocytes. Currently and in contrast to B-lineage ALL, genetic abnormalities are clinically not used for therapy stratification. Further progress on the treatment of T-ALL will require further genetic characterization, which will provide us with a better understanding of the pathogenesis of T-ALL and hopefully will lead to improved treatment schedules. As the general scope of this thesis, we performed genome-wide copy number analysis using array-CGH for the identification of novel genomic rearrangements in T-ALL that possibly relate to treatment outcome, i.e. prognostic factors, or provide further insight in the pathogenesis of T-cell leukemia.
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| , , | |
| Pieters, Prof. Dr. R. (promotor), Sophia Foundation for Medical Research (SSWO grant 404) | |
| R. Pieters (Rob) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/12225 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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van Vlierberghe, P. (2008, April 17). Molecular-genetic insights in pediatric T-cell acute lymphoblastic leukemia. Retrieved from http://hdl.handle.net/1765/12225 |
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