Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Interestingly, the great majority of individuals affected by the tumor have underlying liver disease, therefore narrowing the population to be screened. Still, however, there is a clear lack of blood biomarkers, and surveillance in those at risk is performed by frequent imaging of the liver. A variety of multinational collaborations are currently invested in finding biomarkers for HCC based on liver-produced proteins. A new approach with assessment of peripheral proteins might be necessary for the successful early detection of this malignancy.

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doi.org/10.1016/j.aohep.2019.07.009, hdl.handle.net/1765/122295
Annals of Hepatology
Department of Gastroenterology & Hepatology

Debes, J.D., Carrera, E., Mattos, A.Z., Prieto, J.E., Boonstra, A., Arrese, M., … LaMarca, A. (2019). Hepatocellular carcinoma, a unique tumor with a lack of biomarkers. Annals of Hepatology, 18(6), 786–787. doi:10.1016/j.aohep.2019.07.009