In this dissertation we investigated the role of B cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL) cells of different groups of CLL patients. We investigated to what extent BCR signaling differs from normal B cells and what differences there are between CLL cells of different patients after stimulation of the BCR.
Furthermore, in 3 families with multiple CLL patients examined the characteristics of the BCR and also looked at genetic abnormalities in these families. Because CLL is a disease that mainly affects the elderly, they have finally, we also studied the B cell differentiation and BCR repertoire upon aging.

Additional Metadata
Keywords Chronic lymphocytic leukemia, B cell receptor, signaling, B cell, aging
Promotor J.M. van Dongen (Johannes) , R.W. Hendriks (Rudi) , A.W. Langerak (Anton)
Publisher Erasmus University Rotterdam
ISBN 978-94-91811-25-8
Persistent URL
Muggen, A.F. (2020, January 7). Chronic Lymphocytic Leukemia: The B cell receptor and beyond. Erasmus University Rotterdam. Retrieved from