Acute withdrawal of calcium channel blockers can lead to the so-called calcium channel blocker withdrawal phenomenon, in particular, when high dosages are used. In the case presented, inadequate drug substitution led to this phenomenon which resulted in a serious course of events. Careful monitoring the process of drug substitution with respect to equal therapeutic dosages is therefore a necessity, especially in vulnerable patients.

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The Netherlands Journal of Medicine
Department of Pharmacy

Peeters, L., den Uil, C., Feyz, L., van den Bemt, P., Daemen, J. (J.), & Versmissen, J. (2019). Acute calcium channel blocker withdrawal-induced cardiac arrest. The Netherlands Journal of Medicine, 77(9), 341–343. Retrieved from