Age-related macular degeneration (AMD) is the most important cause of irreversible legal blindness in elderly persons in industrialized countries. AMD has two forms: atrophic (dry) and exudative (wet). In the wet form, abnormal blood vessels, arising from the choriocapillaris (choroidal neovascularization, CNV) underneath the macula, grow through ruptures in the Bruch’s membrane, into the sub-retinal pigment epithelium (RPE) space or into the subretinal space, or a combination of both. Blood and serum leakage from the CNV below the RPE and/or below and within the retina are harmful and fi nally causes irreversible damage to the photoreceptors of the overlying macula which results in a central scotoma.

macular degeneration
J.C. van Meurs (Jan)
Erasmus University Rotterdam
Meurs, Prof. Dr. J.C. van (promotor), SWOO-Flieringa Foundation, Alcon Nederland BV, Allergan BV, Bausch & Lomb, Carl Zeiss BV, D.O.R.C. International BV, Eyetech BV, Laméris Ootech BV, Novartis Pharma BV, Pfizer BV, Thea Pharma Nederland, Tramedico
Erasmus MC: University Medical Center Rotterdam

Maaijwee, K.J.M. (2008, April 18). Autologous Translocation of the Retinal Pigment Epithelium and Choroid in the Treatment of Exudative Age-related Macular Degeneration. Erasmus University Rotterdam. Retrieved from