Controversies exist regarding the classification of the different clinical phases of chronic hepatitis B (CHB) because hepatitis B virus (HBV) DNA and alanine aminotransferase levels fluctuate over time.1,2 To improve the distinction of clinical phases and the associated spectrum of clinical outcome,3,4 hepatitis B surface antigen (HBsAg) levels may be of help.5–7 We hypothesize that HBV genotype specific HBsAg levels are needed for the identification of different clinical HBV disease phases.7

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Journal Clinical Gastroenterology and Hepatology
Brouwer, W.P, Zhao, Q. (Qian), Hansen, B.E, Lau, D. (Daryl), Khalili, M. (Mandana), Terrault, N, … Zadorozny, E. (Ella). (2020). HBV Genotype-Specific Levels of Hepatitis B Surface Antigen Improve HBV Phenotype Definition. Clinical Gastroenterology and Hepatology, 18(1), 259–261. doi:10.1016/j.cgh.2018.12.039