The Effects of a 10-wk Outpatient Pulmonary Rehabilitation Program on Exercise Performance, Muscle Strength, Soluble Biomarkers, and Quality of Life in Patients With Pulmonary Hypertension
Purpose: Pulmonary arterial hypertension (PAH) is characterized by right ventricular failure, leading to exertional dyspnea, skeletal muscle weakness, and poor quality of life (QOL). Apart from treatment with PAH-specifi c drugs, guidelines recommend pulmonary rehabilitation (PR). Clinical PR programs have shown improvement in functional capacity and QOL. However, little is known about the effectiveness of an outpatient PR program. The aim of our study was to assess effectiveness of a multidisciplinary outpatient PR program. Methods: Patients with PAH or chronic thromboembolic pulmonary hypertension (CTEPH), who were in a stable condition on optimized drug therapy, followed a 10-wk outpatient program in a rehabilitation center. The PR program was designed to improve exercise capacity and health status by means of low load cycling, walking, and muscle training twice a week combined with psychological counseling. QOL was measured by the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) questionnaire. Results: Twenty-one patients (13 women) with PAH (n = 16) or CTEPH (n = 5) completed the study. All patients were in New York Heart Association (NYHA) functional class III, and their mean age was 45 ± 16 yr. After PR, the mean cycling endurance time increased by 4.4 min ( P < .001), 6-min walk distance by 12.2 m ( P < .05), and maximum inspiratory pressure by 5.8 cm H 2O ( P = .01). Skeletal muscle function increased signifi - cantly. The CAMPHOR questionnaire demonstrated signifi cant decrease in symptoms and improvement in QOL. Soluble biomarkers did not show any change before and after PR. Conclusions: Outpatient PR could be an effective instrument to improve exercise capacity and health status in patients with PAH or CTEPH.
|Keywords||exercise capacity • pulmonary hypertension • pulmonary rehabilitation therapy • quality of life • soluble biomarkers|
|Persistent URL||dx.doi.org/10.1097/hcr.0000000000000443, hdl.handle.net/1765/123261|
|Journal||Journal of Cardiopulmonary Rehabilitation and Prevention|
Koudstaal, T, Wapenaar - de Korver, M, van Ranst, D., Beesems, R., van der Toorn, L., van den Bosch, A.E, … Boomars, K. (2019). The Effects of a 10-wk Outpatient Pulmonary Rehabilitation Program on Exercise Performance, Muscle Strength, Soluble Biomarkers, and Quality of Life in Patients With Pulmonary Hypertension. Journal of Cardiopulmonary Rehabilitation and Prevention, 39(6), 397–402. doi:10.1097/hcr.0000000000000443