Objectives: The aim is to assess the experience in the Netherlands using the Xposition S self-apposing stent in complex coronary lesions in clinical practice. Background: Treatment of complex coronary lesions could be accompanied with stent sizing difficulties and complications, particularly due to vessel overdilation or stent underexpansion. The self-apposing feature of the Xposition S stent (STENTYS, Paris, France) supports good strut apposition in complex anatomies and allows for an increase in diameter after implantation. Methods: In this real-world registry, data from patients treated with Xposition S in four Dutch clinical sites were prospectively collected and analyzed. Any patient suitable for implantation with Xposition S according to current recommendations was enrolled. Primary endpoint was major adverse cardiac events (MACE) at 1 year. Results: Between 2015 and 2018, data from 251 patients were collected. Clinical presentation was an acute coronary syndrome in majority of the patients (76.9%). Main angiographic indications were lesions in aneurysmatic or ectatic vessels (32.3%), thrombus containing lesions (13.1%), and bifurcation/left main stenosis (10.4%). Most of the target lesions (TLs) were classified as AHA/ACC Type C (53.6%). Despite lesion complexity, device was successfully implanted at TL in 96.8%. MACE rate, reported on patients having completed 1-year follow-up (n = 203), was 6.6%, with low rate of definite/probable stent thrombosis (1.0%). Conclusions: In clinical practice of several Dutch sites, STENTYS Xposition S showed good procedural results and low 1-year clinical events rate, despite complex coronary anatomy.

Additional Metadata
Keywords complex PCI, coronary artery disease, percutaneous coronary intervention, stent design/structure/coatings
Persistent URL dx.doi.org/10.1002/ccd.28192, hdl.handle.net/1765/123294
Journal Catheterization and Cardiovascular Interventions
Citation
Vlieger, S., Simsek, C, Balland, A., Somi, S., Jessurun, G., Amoroso, G, … Ijsselmuiden, A. (2019). Dutch multicenter experience using the STENTYS Xposition S self-apposing stent in complex coronary lesions. Catheterization and Cardiovascular Interventions, 94(7), 966–971. doi:10.1002/ccd.28192