This dissertation describes the use of new molecular markers for the detection and classification of cervical and anal intraepithelial neoplasia. We used HPV genotyping, methylation markers of human tumor suppressor genes and HPV E4 immunohistochemistry in the search for an optimal approach for screening and triage. The results contribute to a future with:
- A screening for cervical cancer where all tests can be performed on one sample that has been taken in the most comfortable way for the woman.
- Better detection of men and women with an increased risk of cervical and anal leions that can lead to cancer.
- Better selection of men and women to be treated, thereby preventing over-treatment of lesions that will be cleared spontaneously.

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F.J. van Kemenade (Folkert) , H.J.C. de Vries (Henry) , W.G.V. Quint (Wim)
Erasmus University Rotterdam
hdl.handle.net/1765/123391

Leeman, A. (2020, March 4). Biomarkers in the Detection and Classification of Cervical and Anal Intraepithelial Neoplasia. Retrieved from http://hdl.handle.net/1765/123391