This dissertation describes the use of new molecular markers for the detection and classification of cervical and anal intraepithelial neoplasia. We used HPV genotyping, methylation markers of human tumor suppressor genes and HPV E4 immunohistochemistry in the search for an optimal approach for screening and triage. The results contribute to a future with:
- A screening for cervical cancer where all tests can be performed on one sample that has been taken in the most comfortable way for the woman.
- Better detection of men and women with an increased risk of cervical and anal leions that can lead to cancer.
- Better selection of men and women to be treated, thereby preventing over-treatment of lesions that will be cleared spontaneously.

Additional Metadata
Keywords AIN, CIN, anal cancer, cervical cancer, HPV, methylation, immunohistochemistry, p16, E4
Promotor F.J. van Kemenade (Folkert) , H.J.C. de Vries (Henry) , W.G.V. Quint (Wim)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-386-6
Persistent URL
Note For copyright reasons there is a partial embargo for this dissertation
Leeman, A. (2020, March 4). Biomarkers in the Detection and Classification of Cervical and Anal Intraepithelial Neoplasia. Erasmus University Rotterdam. Retrieved from