Infectious mononucleosis may mimic lymphoma, both clinically and histopathologically. We present a patient with neurological symptoms and lymphadenopathy, initially diagnosed as Epstein-Barr virus (EBV)-positive angioimmunoblastic T-cell lymphoma (AITL) with cerebrospinal fluid (CSF) localisation based on lymph node pathology and a 30-fold higher EBV load in the CSF compared with serum. However, the patient fully recovered spontaneously and EBV became negative in both CSF and serum, suggestive of a dramatic presentation of EBV meningoencephalitis.

Angioimmunoblastic T-cell lymphoma (AITL), Central nervous system involvement, Epstein-Barr virus (EBV), Mimicking lymphoma
The Netherlands Journal of Medicine

De haes, I. (I.), Versluis, J, Lam, K.H, Jongen, J.L.M. (J. L.M.), Doorduijn, J.K, & Kuipers, S. (S.). (2019). Epstein-Barr virus infection or malignant lymphoma – what you see is not what you get. The Netherlands Journal of Medicine, 77(10), 370–372. Retrieved from