BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality. This prospective study with 3 predetermined timepoints and a standardized treatment protocol investigates changes in sleep parameters during the first 2.5 years of acromegaly treatment. METHODS: Before initiation of acromegaly treatment (medical pretreatment followed by surgery), polysomnography (PSG) was performed in 27 consecutive patients with treatment-naive acromegaly. PSG was repeated after 1 year (N = 24) and 2.5 years (N = 23), and anthropometric and biochemical parameters were obtained. RESULTS: At baseline, 74.1% of the patients was diagnosed with OSAS. The respiratory disturbance index (RDI; P = 0.001), oxygen desaturation index (ODI; P = 0.001), lowest oxygen saturation (LSaO2; P = 0.007) and the Epworth Sleepiness Scale (ESS; P < 0.001) improved significantly during treatment, with the greatest improvement in the first year. After 2.5 years of treatment, all patients had controlled acromegaly. Of the 16 patients with repeated PSG and OSAS at baseline, 11 (68.8%) were cured of OSAS. Changes in RDI, ODI, LSaO2, and ESS correlated with insulin-like growth factor 1 levels. CONCLUSION: OSAS has a high prevalence in active acromegaly. There is a substantial decrease in prevalence and severity of OSAS following acromegaly treatment, with the largest improvement during the first year. Most patients recover from OSAS following surgical or biochemical control of the acromegaly. Therefore, a PSG is advised after diagnosis of acromegaly. When OSAS is present, it should be treated and PSG should be repeated during acromegaly treatment.

acromegaly, Epworth Sleepiness Scale, IGF-1, ODI, RDI, sleep apnea syndrome,
Journal of Clinical Endocrinology and Metabolism
Department of Internal Medicine

Wolters, T.L.C. (Thalijn L C), Roerink, S.H.P.P, Drenthen, L.C.A. (Linda C A), van Haren-Willems, J.H.G.M. (Jolanda H G M), Wagenmakers, M.A.E.M, Smit, J.W.A, … Netea-Maier, R.T. (2019). The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment. Journal of Clinical Endocrinology and Metabolism, 105(1). doi:10.1210/clinem/dgz050