The aim of this thesis is to investigate whether insulin resistance, inflammation and oxidative stress increase CV risk and affect survival in high-risk populations.
To addressthis question, epidemiologic and genetic studies were carried out in obese individuals, elderly and patients with chronic kidney disease of various severity, who represent three populations with high CV risk.

F.U.S. Mattace Raso (Francesco) , E.J.G. Sijbrands (Eric) , G.L. Tripepi (Giovanni)
Erasmus University Rotterdam
Department of Internal Medicine

Spoto, B.G. (2020, January 30). Metabolism, Renal Insufficiency and Life Expectancy : Studies on obesity, chronic kidney diseases and aging. Erasmus University Rotterdam. Retrieved from