Characterizing the complex viscoelastic properties of microbubble shells typically requires experimentally challenging techniques, such as isolating single microbubbles and measuring optically their oscillatory response to well-controlled acoustic driving. Here, we propose a relatively simple alternative method to determine the shell viscosity for a known shell elasticity, which consists of measuring ultrasound radiation force-induced displacements within freely floating microbubble populations using a standard ultrasound-imaging probe. We experimentally tested this technique on lipid-coated microbubbles and verified its accuracy by comparing with measurements made on the oscillatory response of individual microbubbles to ultrasound driving.

microbubbles, primary radiation force, Ultrasound contrast agents, viscoelasticity
dx.doi.org/10.1109/ULTSYM.2019.8925605, hdl.handle.net/1765/123735
2019 IEEE International Ultrasonics Symposium, IUS 2019
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Erasmus MC: University Medical Center Rotterdam

Supponen, O. (Outi), Upadhyay, A. (Awaneesh), Lum, J. (Jordan), Guidi, F. (Francesco), Murray, T. (Todd), Vos, H.J, … Borden, M. (Mark). (2019). Ultrasound radiation force as a method to characterize the viscosity of microbubble shells. In IEEE International Ultrasonics Symposium, IUS (pp. 1070–1073). doi:10.1109/ULTSYM.2019.8925605