This thesis enriches the body of knowledge around pluripotency by describing a novel pluripotent state. It deepens our understanding of cell biology, the processes establishing pluripotency and provides new insights into improving the process of artificial generation of pluripotent cells.

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Keywords pluripotent stem cells, mouse embryonic stem cells, mouse epiblast stem cells, human embryonic stem cells, WNT, MEK, LIF
Promotor E.A. Dzierzak (Elaine) , D. Huylebroeck (Danny) , D. ten Berge (Derk)
Publisher Erasmus University Rotterdam
ISBN 978-94-6375-626-6
Persistent URL
Neagu, A. (2020, January 14). Signal Balance as a Pluripotency Determinant: In vitro modeling of in vivo pluripotency states with WNT, FGF and BMP. Erasmus University Rotterdam. Retrieved from