Aim: Investigate the potential role of OPRM1 (mu-opioid receptor) and COMT (catechol-O-methyltransferase enzyme) polymorphisms in postoperative acute, chronic and experimental thermal pain. Methods: A secondary analysis of 125 adult cardiac surgery patients that were randomized between fentanyl and remifentanil during surgery and genotyped. Results: Patients in the fentanyl group with the COMT high-pain sensitivity haplotype required less postoperative morphine compared with the average-pain sensitivity haplotype (19.4 [16.5; 23.0] vs 34.6 [26.2; 41.4]; p = 0.00768), but not to the low-pain sensitivity group (30.1 [19.1; 37.7]; p = 0.13). No association was found between COMT haplotype and other pain outcomes or OPRM1 polymorphisms and the different pain modalities. Conclusion: COMT haplotype appears to explain part of the variability in acute postoperative pain in adult cardiac surgery patients.

adverse drug reactions, drug transporter genes, pain,
no subscription
Department of Clinical Chemistry

Matić, M, de Hoogd, S, de Wildt, S.N, Tibboel, D, Knibbe, C.A.J, & van Schaik, R.H.N. (2020). OPRM1 and COMT polymorphisms: Implications on postoperative acute, chronic and experimental pain after cardiac surgery. Pharmacogenomics, 21(3), 181–193. doi:10.2217/pgs-2019-0141