Autoimmune diseases associated with Th1/Th17-type cells improve during pregnancy.This is because the Th2-type cytokines are dominant during pregnancy, which is important for the tolerance of the fetal semiallograft. Estrogen and progesterone stimulate the Th2-type cell activity. The innate immune system is usually more active in women. During pregnancy an autoinflammatory syndrome may worsen. Treg cells from the thymus are responsible for the inhibition of the Th1 and Th17 cells during pregnancy. In general, female patients with immune mediated inflammatory diseases should avoid all medicines during a pregnancy. In pregnancy there is an absolute contraindication for methotrexate and mycophenolic acid/mycophenolate mofetil. During pregnancy the biologic certolizumab pegol is the best treatment option for psoriasis.

Additional Metadata
Keywords Autoimmune diseases, Biologics, Drugs, Pregnancy, Th2 cell, Thymus
Persistent URL hdl.handle.net/1765/124210
Journal Nederlands Tijdschrift voor Dermatologie en Venereologie
Citation
Thio, H.B. (2019). Zwangerschap en inflammatoire dermatosen/systeemziekten. Nederlands Tijdschrift voor Dermatologie en Venereologie, 29(3), 6–8. Retrieved from http://hdl.handle.net/1765/124210