Objective: To provide an insightful summary of studies on biochemical markers for osteoarthritis (OA). Design: Two investigators systematically searched the electronic PubMed database for clinical studies into soluble biochemical markers for OA in humans that were published between 01-03-2018 and 01-03-2019. Data from selected publications were systematically extracted and tabulated and were summarized in a narrative review. Results: Out of 1,279 publications, 124 fulfilled all selection criteria and were selected for data extraction. The majority were around knee OA, cross-sectional in design, relatively small, and/or focused on one or a few biochemical markers. Among the intervention studies, relatively many were on non-pharmacological interventions, used clinical outcomes and/or were rather short. Some leads that were provided by this year's studies pertained to less conventional inflammatory mediators, oxidative stress, acidosis, angiogenesis and/or autoantibody formation. Conclusions: This year's biochemical marker studies did provide potential leads for therapeutic targets or other biochemical marker applications that require robust and strategic follow-up research to be validated.

Biomarkers, Diagnosis, Osteoarthritis, Prognosis, Review, Trial
dx.doi.org/10.1016/j.joca.2019.11.007, hdl.handle.net/1765/124242
Osteoarthritis and Cartilage
Department of General Practice

van Spil, W.E, & Szilagyi, I.A. (I. A.). (2020). Osteoarthritis year in review 2019: biomarkers (biochemical markers). Osteoarthritis and Cartilage. doi:10.1016/j.joca.2019.11.007