Venous thromboembolism is a common complication of asparaginase-based chemotherapy regimens for the treatment of acute lymphoblastic leukemia. Thrombosis associated with asparaginase administration poses a number of specific and often clinically challenging management decisions. This review provides guidance on the prevention and treatment of thrombosis associated with asparaginase in adults including discussions on antithrombin repletion, pharmacologic thromboprophylaxis, cerebral venous thrombosis, and therapeutic anticoagulation.

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Keywords acute lymphoblastic leukemia, anticoagulation, antithrombin, asparaginase, cerebral venous thrombosis, venous thromboembolism
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Journal Journal of Thrombosis and Haemostasis
Organisation Department of Hematology
Zwicker, J.I. (Jeffrey I.), Wang, T.-F. (Tzu-Fei), DeAngelo, D.J. (Daniel J.), Lauw, I, Connors, J.M. (Jean M.), Falanga, A. (Anna), … Carrier, M. (Marc). (2020). The prevention and management of asparaginase-related venous thromboembolism in adults: Guidance from the SSC on Hemostasis and Malignancy of the ISTH. Journal of Thrombosis and Haemostasis, 18(2), 278–284. doi:10.1111/jth.14671