An insulinoma is a neuroendocrine tumor of the pancreas, arising from the β-cell, resulting in endogenous hyperinsulinemia. This causes hypoglycemia with neurogycopenic symptoms. Diagnosis of insulinoma starts with demonstrating elevated insulin during a spontaneous hypoglycemia or a hypoglycemia can be provoked by a 72-h fasting test. Most insulinomas are benign and localized to the pancreas and can be surgically resected. Rare metastastic insulinomas are treated with diazoxide or somatostatin analogues.

Functional neuroendocrine tumors, Hypoglycemia, Insulinoma, Neuroendocrine tumor,
Erasmus MC: University Medical Center Rotterdam

Zandee, W.T, & de Herder, W.W. (2018). Insulinoma. In Encyclopedia of Endocrine Diseases (pp. 58–62). doi:10.1016/B978-0-12-801238-3.65228-5