An insulinoma is a neuroendocrine tumor of the pancreas, arising from the β-cell, resulting in endogenous hyperinsulinemia. This causes hypoglycemia with neurogycopenic symptoms. Diagnosis of insulinoma starts with demonstrating elevated insulin during a spontaneous hypoglycemia or a hypoglycemia can be provoked by a 72-h fasting test. Most insulinomas are benign and localized to the pancreas and can be surgically resected. Rare metastastic insulinomas are treated with diazoxide or somatostatin analogues.

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Keywords Functional neuroendocrine tumors, Hypoglycemia, Insulinoma, Neuroendocrine tumor
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Zandee, W.T, & de Herder, W.W. (2018). Insulinoma. In Encyclopedia of Endocrine Diseases (pp. 58–62). doi:10.1016/B978-0-12-801238-3.65228-5