Clinical and Pathological Aspects of Small Bowel and Appendiceal Cancer: Insights into rare entities

In daily practice, patients with small bowel and appendiceal cancers have historically been treated in a similar fashion as frequently encountered gastrointestinal cancers, mainly as colorectal or gastric cancer. However, the rationale for this extrapolation is not evidence-based and therefore, this thesis aimed to provide insights into clinical and pathological aspects of these two rare gastrointestinal cancers. It was shown that small bowel and appendiceal cancer both have a distinct clinical disease course, compared to other gastrointestinal cancers. Metastatic disease was common in patients with SBA, and only a minority was treated with palliative systemic treatment. An oxaliplatin-containing regimen could be a suggested frontline regimen, without the addition of the targeted agent bevacizumab. In appendiceal cancer, histologic subtype is of prognostic relevance in mainly peritoneal disease, and it is of utmost importance to classify patients with mucinous appendiceal neoplasms according to the latest proposed consensus-based classification for prognostic and treatment purposes.

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