2020-02-12
Cognitive profiles discriminate between genetic variants of behavioral frontotemporal dementia
Publication
Publication
Journal of Neurology: official journal of the European Neurological Society
Introduction: Trials to test disease-modifying treatments for frontotemporal dementia are eagerly awaited and sensitive instruments to assess potential treatment effects are increasingly urgent, yet lacking thus far. We aimed to identify gene-specific instruments assessing clinical onset and disease progression by comparing cognitive functioning between bvFTD patients across genetic mutations. Methods: We examined differences in 7 cognitive domains between bvFTD patients with GRN (n = 20), MAPT (n = 29) or C9orf72 (n = 31) mutations, and non-carriers (n = 24), and described longitudinal (M = 22.6 months, SD = 16.6) data in a subsample (n = 27). Results: Patients showed overall cognitive impairment, except memory recall, working memory and visuoconstruction. GRN patients performed lower on executive function (mean difference − 2.1; 95%CI − 4.1 to − 0.5) compared to MAPT and lower on attention compared to MAPT (mean difference − 2.5; 95%CI − 4.7 to − 0.3) and C9orf72 (mean difference − 2.4; 95%CI − 4.5 to − 0.3). Only MAPT patients were impaired on delayed recall (mean difference − 1.4; 95%CI − 2.1 to − 0.7). GRN patients declined rapidly on attention and memory, MAPT declined in confrontation naming, whereas C9orf72 patients were globally impaired but remained relatively stable over time on all cognitive domains. Discussion: This study shows gene-specific cognitive profiles in bvFTD, which underlines the value of neuropsychological tests as outcome measures in upcoming trials for genetic bvFTD.
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doi.org/10.1007/s00415-020-09738-y, hdl.handle.net/1765/124885 | |
Journal of Neurology: official journal of the European Neurological Society | |
Organisation | Department of Neurology |
Poos, J., Jiskoot, L., Leijdersdorff, S., Seelaar, H., Panman, J., van der Ende, E., … van den Berg, E. (2020). Cognitive profiles discriminate between genetic variants of behavioral frontotemporal dementia. Journal of Neurology: official journal of the European Neurological Society. doi:10.1007/s00415-020-09738-y |