Conditional Survival After Resection for Pancreatic Cancer: A Population-Based Study and Prediction Model
Background: Conditional survival is the survival probability after already surviving a predefined time period. This may be informative during follow-up, especially when adjusted for tumor characteristics. Such prediction models for patients with resected pancreatic cancer are lacking and therefore conditional survival was assessed and a nomogram predicting 5-year survival at a predefined period after resection of pancreatic cancer was developed. Methods: This population-based study included patients with resected pancreatic ductal adenocarcinoma from the Netherlands Cancer Registry (2005–2016). Conditional survival was calculated as the median, and the probability of surviving up to 8 years in patients who already survived 0–5 years after resection was calculated using the Kaplan–Meier method. A prediction model was constructed. Results: Overall, 3082 patients were included, with a median age of 67 years. Median overall survival was 18 months (95% confidence interval 17–18 months), with a 5-year survival of 15%. The 1-year conditional survival (i.e. probability of surviving the next year) increased from 55 to 74 to 86% at 1, 3, and 5 years after surgery, respectively, while the median overall survival increased from 15 to 40 to 64 months at 1, 3, and 5 years after surgery, respectively. The prediction model demonstrated that the probability of achieving 5-year survival at 1 year after surgery varied from 1 to 58% depending on patient and tumor characteristics. Conclusions: This population-based study showed that 1-year conditional survival was 55% 1 year after resection and 74% 3 years after resection in patients with pancreatic cancer. The prediction model is available via www.pancreascalculator.com to inform patients and caregivers.
|Keywords||Conditional survival, Pancreatic cancer, Prediction model, Survival|
|Persistent URL||dx.doi.org/10.1245/s10434-020-08235-w, hdl.handle.net/1765/124903|
|Journal||Annals of Surgical Oncology|
Latenstein, A.E.J. (Anouk E. J.), van Roessel, S. (Stijn), van der Geest, L.G.M, Bonsing, B.A, Dejong, C.H.C. (Cornelis H. C.), Groot Koerkamp, B, … Besselink, M.G. (2020). Conditional Survival After Resection for Pancreatic Cancer: A Population-Based Study and Prediction Model. Annals of Surgical Oncology. doi:10.1245/s10434-020-08235-w