This thesis aimed to provide more insight into clinical and biological factors influencing the quality of life of Inflammatory Bowel Disease patients. As clinicians and researchers, we tend to focus more on disease specific symptoms and objective disease markers and less on the quality of life which is one of the most important outcomes for patients. Therefore, little knowledge regarding determinants of quality of life are available and much remains unknown. In particular the pathophysiology of subjective symptoms such as fatigue, sleep and mood and their relation to IBD is unclear. This thesis started with exploring the current knowledge of the disabling symptom of fatigue in IBD patients followed by the assessment of the effect of new biological therapies on psychosocial symptoms such as fatigue, sleep and mood. The last part of this thesis used newly developed research technologies, known as ‘omics research, to investigate the underlying mechanism of fatigue in IBD and to identify the impact of family history on the natural history of IBD.

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Keywords Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis, Fatigue, Quality of life, biological therapy, microbiome
Promotor C.J. van der Woude (Janneke) , A.N. Ananthakrishnan (Ashwin)
Publisher Erasmus University Rotterdam
ISBN 978-94-6380-707-4
Persistent URL hdl.handle.net/1765/124942
Citation
Borren, N.Z. (2020, September 16). Quality of Life in Inflammatory Bowel Disease: When IBD goes beyond the gut. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/124942

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