Surgery of long bone metastases is associated with a significant risk of perioperative blood loss, which may necessitate blood transfusion. Successful embolization (> 70% obliteration of vascularity) can be achieved in 36-75% of cases. The reported rate of embolization-related complications is 0-9%. Three out of six level III evidence studies showed a reduction in perioperative blood loss and/orblood transfusion requirement after preoperative embolization of renal cell carcinoma metastasis in long bones; three out of six studies did not. One level III evidence study did not show a reduction in perioperative blood loss and/or transfusion requirement after preoperative embolization of hepatocellular carcinoma metastases in long bones. There were no studies found that support preoperative embolization of thyroid metastases or other frequent long bone metastases (e.g. mamma carcinoma, lung carcinoma, or prostate carcinoma). The clinical level of evidence of the studies found is low and randomized studies taking into account primary tumour, location of metastases and type of surgery are therefore desired.

Bone metastases, Embolization, Long bones, Pathological fractures, Surgical treatment,
EFORT Open Reviews
Department of Orthopaedics

Geraets, S.E.W. (Stijn E. W.), Bos, P.K, & van der Stok, J. (2020). Preoperative embolization in surgical treatment of long bone metastasis: A systematic literature review. EFORT Open Reviews, 5(1), 17–25. doi:10.1302/2058-5241.5.190013