Potential benefits of the use of sympathomimetics for asthmatic disease, on semen quality in men of subfertile couples
Research question: Is there an association between the use of sympathomimetics for asthmatic disease and semen quality in humans? Design: Between 2007 and 2012 a prospective cohort study was conducted among couples visiting the preconception counselling clinic at a tertiary hospital in the Netherlands. The study included 882 men of subfertile couples and information on medication use was obtained from self-administered questionnaires. Moreover, data on semen parameters were retrieved from medical records. Results: The study population of men revealed a mean (± SD) age of 34 ± 4 years with a mean body mass index (BMI) of 26.1 ± 2.3 kg/m2, and sympathomimetic use was reported by 3.6%. The use of sympathomimetics was positively associated with a 10% higher sperm motility (beta 10.265; 95% confidence interval [CI] 3.258–17.272) after adjustment for smoking, alcohol use, age, geographic background, BMI, folic acid supplement use, the four astronomical seasons and asthma/bronchitis. Subgroup analysis between men with total motile sperm count (TMSC) < or ≥10 million showed that this association remained (P ≤ 0.001) after adjustment for these confounders. After adjustment for confounders the sperm concentration was also positively associated with the use of sympathomimetics, but only in men with TMSC ≥10 million (beta 0.300; 95% CI 0.032–0.568). Conclusions: These preliminary data show the potential benefits of the use of sympathomimetics to improve sperm motility in men of subfertile couples, which needs further investigation.
|Drug utilization, Respiratory medicine, Semen parameters, Sympathetic nervous system|
|Reproductive BioMedicine Online: an international journal devoted to biomedical research on human conception and the welfare of the human embryo|
|Organisation||Department of Gynaecology & Obstetrics|
Oostingh, E.C. (Elsje C.), Otte-Huijgen, N.A, Koedooder, R. (Rivka), Dohle, G.R, Stricker, B.H.Ch, & Steegers-Theunissen, R.P.M. (2019). Potential benefits of the use of sympathomimetics for asthmatic disease, on semen quality in men of subfertile couples. Reproductive BioMedicine Online: an international journal devoted to biomedical research on human conception and the welfare of the human embryo. doi:10.1016/j.rbmo.2019.12.009