A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation
Background: End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation. Results: Circulating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positive naive T cells (as a marker for recent thymic emigrants) and the differentiation status of the memory T cells was assessed. Thirty recipients died during follow-up of at least 5 years. Absolute numbers of naive CD4+ (living:258 cells/μl vs. deceased:101 cells/μl, p < 0.001) and naive CD8+ T cells (living:97 cells/μl vs. deceased:37 cells/μl, p < 0.001) were significantly lower in the deceased group prior to transplantation. In a multivariate proportional hazard analysis the number of naive CD4+ T cells remained associated with all-cause mortality (HR 0.98, CI 0.98-0.99, p < 0.001). The low number of naive T cells in the deceased patient group was primarily caused by a decrease in recent thymic emigrants (i.e. less CD31+ naive T cells) indicating a lowered thymus function. In addition, the physiological age-related compensatory increase in CD31- naïve T cells was not observed. Within the first year after transplantation, the number and characteristics of naive T cells remained stable. Conclusions: A severe reduction in circulating naïve T cells because of a decrease in recent thymic emigrants is highly associated with all-cause mortality after renal transplantation.
|Keywords||Kidney transplantation, Mortality, naïve T cells, recent thymic emigrants, Premature ageing, Thymus|
|Persistent URL||dx.doi.org/10.1186/s12979-020-00175-z, hdl.handle.net/1765/125355|
|Journal||Immunity and Ageing|
Betjes, M.G.H, Langerak, A.W, Klepper, M, & Litjens, N.H.R. (2020). A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation. Immunity and Ageing, 17(1). doi:10.1186/s12979-020-00175-z