Drug disposition in children is impacted by developmental changes in drug absorption, distribution, metabolism and excretion. This mandates the need for dosing regimens specifically tailored to children. Yet, there are gaps in the knowledge on these developmental changes, for example regarding hepatic and renal drug transport and cytochrome P450 (CYP)3A metabolism, putting children at risk for subtherapeutic or toxic drug exposure. Pediatric drug research is faced with ethical and analytical challenges. This thesis addresses these knowledge gaps and challenges by using innovative study designs.

Additional Metadata
Keywords Maturatie, geneesmiddelmetabolisme, geneesmiddeltransport, CYP3A
Promotor D. Tibboel (Dick) , S.N. de Wildt (Saskia) , K.M. Allegaert (Karel)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-396-5
Persistent URL hdl.handle.net/1765/125549
Note For copyright reasons there is a partial embargo for this dissertation
Citation
van Groen, B. (2020, June 17). From Baby Steps To Mature Strides: Maturation of drug metabolism and transport studied using innovative approaches. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/125549