2020-06-17
From Baby Steps To Mature Strides: Maturation of drug metabolism and transport studied using innovative approaches
Publication
Publication
Van babystapjes naar volgroeide sprongen: Maturatie van geneesmiddelmetabolisme en transport bestudeerd met behulp van innovatieve methodes
Drug disposition in children is impacted by developmental changes in drug absorption, distribution, metabolism and excretion. This mandates the need for dosing regimens specifically tailored to children. Yet, there are gaps in the knowledge on these developmental changes, for example regarding hepatic and renal drug transport and cytochrome P450 (CYP)3A metabolism, putting children at risk for subtherapeutic or toxic drug exposure. Pediatric drug research is faced with ethical and analytical challenges. This thesis addresses these knowledge gaps and challenges by using innovative study designs.
| Additional Metadata | |
|---|---|
| , , , | |
| D. Tibboel (Dick) , S.N. de Wildt (Saskia) , K.M. Allegaert (Karel) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/125549 | |
| Organisation | Department of Pediatric Surgery |
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van Groen, B. (2020, June 17). From Baby Steps To Mature Strides: Maturation of drug metabolism and transport studied using innovative approaches. Retrieved from http://hdl.handle.net/1765/125549 |
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| Additional Files | |
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| stellingen-bianca-van-groen.pdf , 419kb | |
| 125549_Chapter_1-General_introduction.pdf Final Version , 719kb | |
| 125549_Chapter_3-Incorporating_ontogeny_in_physiologicall.pdf Final Version , 2mb | |
| 125549_Chapter_4-Proteomics_of_human_liver_membrane_trans.pdf Final Version , 1mb | |
| 125549_Chapter_5-A_comprehensive_analysis_of_ontogeny_of.pdf Final Version , 7mb | |
| 125549_Chapter_6-Alternative_splicing_of_the_SLCO1B1_gene.pdf Final Version , 3mb | |
| 125549_Chapter_7-Dose-linearity_of_the_pharmacokinetics_o.pdf Final Version , 1mb | |
| 125549_Chapter_8-The_oral_bioavailability_and_metabolism.pdf Final Version , 3mb | |
| 125549_Chapter_9-Proof_of_concept.pdf Final Version , 1mb | |
| 125549_Chapter_11-Summary_samenvatting.pdf Final Version , 731kb | |
| Cover-image.PNG Cover Image , 92kb | |
