Cellular thyroid hormone homeostasis requires adequate function of: (1) thyroid hormone transporter proteins at the plasma membrane, (2) deiodinating enzymes and (3) nuclear thyroid hormone receptors (TRs). Defects in any of these processes give rise to distinct disease entities, collectively called thyroid hormone signaling disorders. Thyroid hormone analogues hold therapeutic potential in thyroid hormone signaling disorders by bypassing defective transporters or binding to mutant TRs. This review will focus on the application of analogues in thyroid hormone signaling disorders, particularly monocarboxylate transporter (MCT)8 deficiency, and resistance to thyroid hormone due to mutations in TRβ (RTHβ)

Additional Metadata
Keywords MCT8, Resistance to thyroid hormone, Thyroid hormone analogues, Triac, TRβ
Persistent URL dx.doi.org/10.1016/j.ando.2020.03.004, hdl.handle.net/1765/125563
Journal Annales d'Endocrinologie
Citation
Visser, W.E. (2020). Therapeutic applications of thyroid hormone analogues. Annales d'Endocrinologie. doi:10.1016/j.ando.2020.03.004