Post-extubation stridor after prolonged intubation in the pediatric intensive care unit (PICU): a prospective observational cohort study
Purpose: Prolonged endotracheal intubation may lead to laryngeal damage, with stridor being the most relevant clinical symptom. Our objective was to determine the incidence of post-extubation stridor and their clinical consequences in children within a tertiary referral center and to identify contributing factors. Methods: 150 children, aged 0–16 years, intubated for more than 24 h were prospectively enrolled until discharge of the hospital. Potential relevant factors, thought to mediate the risk of laryngeal damage, were recorded and analyzed. Results: The median duration of intubation was 4 days, ranging from 1 to 31 days. Stridor following extubation occurred in 28 patients (18.7%); 3 of them required reintubation due to respiratory distress and in 1 child stridor persisted for which a surgical intervention was necessary. In multivariate analyses, we found the following independent predictors of stridor: intubation on the scene, the use of cuffed tubes and lower age. Conclusion: Despite a high incidence for post-extubation stridor, only few children need reintubation or surgical intervention as a result of post-extubation lesions. Intubation on the scene, the use of cuffed tubes and young age are associated with a significant increased risk of post-extubation stridor. Awareness of these factors gives the possibility to anticipate on the situation and to minimize laryngeal injury and its possible future consequences.
|Keywords||Complications, Endotracheal tube, Laryngeal damage, Laryngotracheal stenosis, Pediatric airway, Prolonged intubation, Stridor, Subglottic stenosis|
|Persistent URL||dx.doi.org/10.1007/s00405-020-05877-0, hdl.handle.net/1765/125596|
|Journal||European Archives of Oto-Rhino-Laryngology|
Veder, L.L, Joosten, K.F.M, Schlink, K. (K.), Timmerman, M.K, Hoeve, L.J, van der Schroeff, M.P, & Pullens, B. (2020). Post-extubation stridor after prolonged intubation in the pediatric intensive care unit (PICU): a prospective observational cohort study. European Archives of Oto-Rhino-Laryngology. doi:10.1007/s00405-020-05877-0