Radiomics uses multiple image features from medical imaging data to predict clinical variables. Various features can be constructed to describe the properties of the full image, or those of a specific region of interest such as a tumor. These features may be related to a wide variety of clinical variables, such as disease characteristics, genetics, and therapy response. This can be done through the use of machine learning, which enables the training of a model on these features using data of patients for which the relevant clinical variables are already known. The resulting models may be used as a diagnostic aid for the prediction of labels such as tumor phenotype and therapy response in new patients. Thereby, radiomics can provide a noninvasive alternative for invasive procedures, such as biopsies, to uncover disease characteristics or clinical outcomes. Radiomics therefore has a high potential to be a valuable tool for clinical practice. This may explain the rise in popularity of radiomics in the medical imaging research field in recent years, resulting in many methods and applications. This chapter provides a guide through the several aspects of designing a radiomics study.

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Keywords Computer aided diagnosis, Features, Machine learning, Radiomics
Persistent URL dx.doi.org/10.1016/B978-0-12-816176-0.00023-5, hdl.handle.net/1765/126021
Citation
Starmans, M.P.A, Voort, S.R. (Sebastian R. van der), Tovar, J.M.C. (Jose M. Castillo), Veenland, J.F, Klein, S, & Niessen, W.J. (2019). Radiomics. In Handbook of Medical Image Computing and Computer Assisted Intervention (pp. 429–456). doi:10.1016/B978-0-12-816176-0.00023-5