Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.

Additional Metadata
Keywords DNA damage, DNA repair, metabolism, pentose phosphate pathway, redox
Persistent URL dx.doi.org/10.1080/23723556.2020.1733383, hdl.handle.net/1765/126076
Journal Molecular and Cellular Oncology
Citation
Milanese, C, & Mastroberardino, P.G. (2020). A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance. Molecular and Cellular Oncology. doi:10.1080/23723556.2020.1733383