A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Milanese, Chiara; Mastroberardino, Pier

doi:10.1080/23723556.2020.1733383

C. Milanese (Chiara) and P.G. Mastroberardino (Pier)

2020-03-22

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Molecular and Cellular Oncology

Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.

Additional Metadata
Keywords	DNA damage, DNA repair, metabolism, pentose phosphate pathway, redox
Persistent URL	doi.org/10.1080/23723556.2020.1733383, hdl.handle.net/1765/126076
Journal	Molecular and Cellular Oncology
Organisation	Erasmus MC: University Medical Center Rotterdam
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	Milanese, C., & Mastroberardino, P. (2020). A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance. Molecular and Cellular Oncology. doi:10.1080/23723556.2020.1733383

Free Full Text ( Final Version , 2mb )

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Publication

Publication

About

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Publication

Publication

Workflow

Workflow

Add Content