2020-04-05
Propofol in neonates causes a dose-dependent profound and protracted decrease in blood pressure
Publication
Publication
Aim: To analyse the effects of different propofol starting doses as premedication for endotracheal intubation on blood pressure in neonates. Methods: Neonates who received propofol starting doses of 1.0 mg/kg (n = 30), 1.5 mg/kg (n = 23) or 2.0 mg/kg (n = 26) as part of a previously published dose-finding study were included in this analysis. Blood pressure in the 3 dosing groups was analysed in the first 60 minutes after start of propofol. Results: Blood pressure declined after the start of propofol in all 3 dosing groups and was not restored 60 minutes after the start of propofol. The decline in blood pressure was highest in the 2.0 mg/kg dosing group. Blood pressure decline was mainly dependent on the initial propofol starting dose rather than the cumulative propofol dose. Conclusion: Propofol causes a dose-dependent profound and prolonged decrease in blood pressure. The use of propofol should be carefully considered. When using propofol, starting with a low dose and titrating according to sedative effect seems the safest strategy.
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| doi.org/10.1111/apa.15282, hdl.handle.net/1765/126483 | |
| Acta Paediatrica: promoting child health | |
| Organisation | Department of Pediatrics |
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de Kort, E., Twisk, J., van t Verlaat, E.P.G. (Ellen P. G.), Reiss, I., Simons, S., & van Weissenbruch, M. (2020). Propofol in neonates causes a dose-dependent profound and protracted decrease in blood pressure. Acta Paediatrica: promoting child health. doi:10.1111/apa.15282 |
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